The escape happened late last night, there was no word at the time of anyone who escaped until the Detention Center did a final count.
The officers found that 27-year-old Tyshon Johnson, 20-year-old Curtis Green and 27-year-old Christopher Boltin escaped.
Two of which are charged with murder.
Earlier this afternoon, Sheriff Ravenell spoke about the efforts being taken in trying to catch the inmates.
Ravenell says he believes this breakout was organized by the inmates, and not just a random act.
He says the inmates should be considered a danger to the community and everyone should be vigilant.
If anyone has any information on the breakout or the escapees whereabouts, they are asked to call the Orangneburg County Sheriff's Office immediately at 803-534-3550 or Crimestoppers at 1-888-CRIME-SC. Callers can remain anonymous.